Rashim Singh
Research Assistant Professor of Pharmaceutics
Department of Pharmacological and Pharmaceutical Sciences
Office
University of Houston College of Pharmacy
Health 2, Room N/A
4349 Martin Luther King Boulevard
Houston, TX 77204-5037
Contact
Research
- Colorectal cancer chemoprevention in high-risk populations: development and optimization of sex-stratified Pirc rat models of Familial Adenomatous Polyposis (FAP) for preclinical efficacy trials and combination therapy development
- Colon-targeted drug and probiotic delivery systems for site-specific action in gastrointestinal disease
- Reduction of gut oxidative stress and inflammation through recycled dietary polyphenols for colorectal cancer prevention
- Drug Metabolism and Pharmacokinetics (DMPK): interplay of Phase II drug metabolizing enzymes (UGTs, SULTs) and efflux/uptake transporters in intestinal and hepatic drug disposition
- Enterohepatic and hepatoenteric recycling of polyphenols and phenolic drugs: mechanistic characterization and PBPK/PD modeling
- Solutions for drug-induced toxicity: chemotherapy-induced diarrhea and buprenorphine induced dental toxicity
- Live Biotherapeutics: engineered bacteria with genetic biocontainment for prevention of chemotherapy-induced gut injury
- Ph.D. in Pharmaceutics, College of Pharmacy, University of Houston, Houston, TX
- Masters in Pharmaceutical Technology (Formulation), National Institute of Pharmaceutical Education and Research (NIPER), Punjab, India
- Bachelor in Pharmacy (B.Pharm), Institute of Technology, Banaras Hindu University, Varanasi, India
- Bui D, Yin T, Duan S, Wei B, Yang P, You M, Singh R, Hu M. Pharmacokinetic Characterization and Bioavailability Barrier for The Key Active Components of Herbal Supplement Antitumor B in Mice for Chemoprevention of Oral Cancer (Journal of Natural Product, DOI: 10.1021/acs.jnatprod.1c00501)
- Tu Y, Wang L, Rong Y, Tin T, Gao S, Singh R, and Hu M. Hepatoenteric Recycling: A New Disposition Mechanism for Orally Administered Phenolic Drugs and Phytochemicals. Elife. 2021 Jul 1;10:e58820.
- Bui D, Li L, Yin T, Wang X, Gao S, You M, Singh R, and Hu M. Pharmacokinetic and metabolic profiling of Magnolia officinalis extract key active components against oral cancer using a validated LC-MS/MS method. J Agric Food Chem 2020, 68, 24, 6576-6587
- Singh R, Lu R, and Hu M. "Flavonoids Interference in Common Protein Assays: Effect of Position and Degree of Hydroxyl Substitution." Anal Biochem. 2020 May 15;597:113644
- Yun C, Dashwood WM, Kwong LN, Gao S, Yin T, Ling Q, Singh R, Dashwood RH, Hu M. Accurate quantification of PGE2 in the polyposis in rat colon (Pirc) model by surrogate analyte-based UPLC-MS/MS. J Pharm Biomed Anal. 2018 Jan 30;148:42-50.
- Meng S, Wu B, Singh R, Yin T, Morrow JK, Zhang S, Hu M. SULT1A3-mediated regiospecific 7-O-sulfation of flavonoids in Caco-2 cells can be explained by the relevant molecular docking studies. Mol Pharm. 2012 Apr 2;9(4):862-73.
- Singh R, Wu B, Tang L and Hu M. Uridine diphosphate glucuronosyltransferase isoform-dependent regiospecificity of glucuronidation of flavonoids. J Agric Food Chem 2011, 59(13):7452-64.
- Yang Z, Zhu W, Gao S, Xu H, Wu B, Kulkarni K, Singh R, Tang L, Hu M. Simultaneous determination of genistein and its four phase II metabolites in blood by a sensitive and robust UPLC-MS/MS method: Application to an oral bioavailability study of genistein in mice. J Pharm Biomed Anal. 2010 Sep 21;53(1):81-9.
- Singh R, Wu B and Hu M. Identification of the Position of Mono-O-Glucuronide of Flavones and Flavonols by Analyzing Shift in Online UV Spectrum (λmax) Generated from an Online Diode-arrayed Detector. J Agric Food Chem 2010, 58(17):9384-95
- Wu B, Morrow J K, Singh R, Zhang S and Hu M. Three dimensional Quantitative Structure-activity Relationship Studies on UGT1A9-mediated 3-O-Glucuronidation of Natural Flavonols Using a Pharmacophore-based Comparative Molecular Field Analysis Model. J Pharmacol Exp Ther 2010, 336(2):403-13.
- Tang L, Singh R, Liu Z and Hu M. Structure and Concentration Changes Affect Characterization of UGT Isoform-Specific Metabolism of Isoflavones. Molecular Pharmaceutics 2009, 6(5):1466-82.
- Xu H, Kulkarni K, Singh R, Yang Z, Wang S, Tam V and Hu M. Disposition of Naringenin Differs from Apigenin and Is Affected by Compensating Efflux Transporters of Hydrophilic Glucuronides. Molecular Pharmaceutics, 2009, 6(6):1703-15.
- Yang G, Ge S, Singh R, Basu S, Shatzer K, Zen M, Liu J, Tu Y, Zhang C, Wei J, Shi J, Zhu L, Liu Z, Wang Y, Gao S, Hu M. Glucuronidation: driving factors and their impact on glucuronide disposition. Drug Metab Rev. 2017;49(2):105-138
- Singh R and Hu M. "Drug Metabolism in Gastrointestinal Tract" in Oral Bioavailability: Basic Principles, Advanced Concepts and Applications, Eds. M. Hu and X. Li. Wiley Press 2011, pg 91-110
- AAISCR Madhabi Ganguly Memorial Award for Entrepreneur-Scientist in Cancer Research, American Association of Indian Scientists in Cancer Research (2026)
- President's Circle Award for Major Grants in 2023–2024, University of Houston (2025)
- K12 Scholar, Consortium for Translational and Precision Health (CTPH), Baylor College of Medicine and University of Houston (2025–2027)
- Adjunct Assistant Professor, Department of Medicine, Baylor College of Medicine (2025–present)
- UHTB Innov8 Hub Pitch Competition Winner, University of Houston Technology Bridge (2024)
- Co-founder, President and CEO, Sanarentero LLC — recipient of three NIH SBIR/STTR grants (R41/R43) for gut health biotechnology (2019–present)
- Annual USA Research Award, Biocodex Microbiota Foundation (2018)
- NIH Postdoctoral Training Fellowship, NIGMS Re-entry into Biomedical Research Supplement (2016–2018)
- NIH Pre-doctoral Training Fellowship, Pharmacoinformatics Program, Keck Center of Gulf Coast Consortia (2007–2009)
- Outstanding Chair Award, AAPS Student Chapter, University of Houston (2008)
- Yoginder Nath Goel & Swaran Lata Goel Academic Achievement Award Endowed Scholarship, University of Houston College of Pharmacy (2008)
- University Gold Medal and "Arun & Malvia" Medal, First Rank, Banaras Hindu University (2001)
- Prof. M.L. Schroff Award, Indian Pharmaceutical Congress (IPC), All-India First Rank in Undergraduate Major (2001)
- GP NAIR Award, Indian Drug Manufacturers Association (IDMA), All-India First Rank in Undergraduate Major (2001)